Formulation of a therapeutic cationic liposome-siRNA complex for development to fight osteosarcoma
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چکیده
منابع مشابه
Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma
OBJECTIVES The tumor suppressor p53 plays a crucial role in the development of osteosarcoma. The primary objective of this study is to develop and optimize lipid based nanoparticle formulations that can carry siRNA and effectively silence mutant p53 in 318-1, a murine osteosarcoma cell line. METHODS The nanoparticles were composed of a mixture of two lipids (cholesterol and DOTAP) and either ...
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A novel cationic cholesterol derivative-based small interfering RNA (siRNA) interference strategy was suggested to inhibit Notch1 activation in SKOV3 cells for the gene therapy of ovarian cancer. The cationic cholesterol derivative, N-(cholesterylhemisuccinoyl-amino-3-propyl)-N, N-dimethylamine (DMAPA-chems) liposome, was incubated with siRNA at different nitrogen-to-phosphate ratios to form st...
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Gene delivery via transferrin receptors, which are highly expressed by cancer cells, can be used to enhance the effectiveness of gene therapy for cancer. In this study, we examined the efficacy of p53 gene therapy in human osteosarcoma (HOSM-1) cells derived from the oral cavity using a cationic liposome supplemented with transferrin. HOSM-1 cells were exposed to transferrin-liposome-p53 in vit...
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ژورنال
عنوان ژورنال: Journal of Shahid Sadoughi University of Medical Sciences
سال: 2019
ISSN: 2228-5733,2228-5741
DOI: 10.18502/ssu.v26i12.660